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Despite advances in chemotherapy, radiotherapy, and targeted therapies, challenges such as poor drug accumulation, systemic toxicity, and multidrug resistance persist, partly due to elevated intracellular GSH levels that neutralize reactive therapeutics and reduce treatment response

Smith et al., 2011

Epub 2012 Nov 29

This non-specific action can also interfere with the physiological signaling roles of ROS (as discussed in Section 2.2), potentially leading to unintended adverse effects or a lack of targeted efficacy