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FERROPTOSIS-RELATED SIGNALING PATHWAYS IN CANCER DRUG RESISTANCE Oxidative damage-related signaling pathways Canonical GPX4-regulated signaling pathway GPX4, a key member of the glutathione peroxidase family, plays a critical role in the modulation of ferroptosis by converting lipid hydroperoxides into inert lipid alcohols, thus preventing their accumulation and protecting cellular membranes

Moreover, they also found that such noise exposure potentiated age-related SNHL, also by disrupting cochlear ribbon synapses immediately post noise exposure, leading to selective SGN axonal fiber loss without destroying cochlear sensory cells (Kujawa and Liberman, 2009

de Moerloose, P., Boehlen, F

After highlighting the in vivo antithrombotic role of OroA, we further determined the cardioprotective effects of OroA on MI expansion and microthrombosis caused by ischemia