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Currently, investigators are emphasizing the development of smart nanogels that respond to environmental stimuli, like temperature, pH, or magnetic fields, to acquire controlled and site-specific release of drugs

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Furthermore, intradermally administered nanoparticles interact intimately with dermal immune cells, such as dendritic cells and macrophages, thereby modulating local immune responses and reducing systemic exposure, which enhances therapeutic efficacy, biocompatibility, and patient safety

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24 hours) induces cytotoxicity in MG63 cells in a dose-dependent manner [2]

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