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This may be due to the need to scavenge reactive oxygen species to recover their injury threshold and thus delay the onset of pain

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Several studies have shown an association between the metabolic programming of obesity by adverse conditions during gestation and the presence of lower Lepr mRNA levels in the hypothalamus (often accompanied by a decrease in the expression of the insulin receptor), as well as an alteration in leptin signalling [73,74,75,76]

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J Nutr Biochem 133(3):941S-947S

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Brain Res 902(1):92

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