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Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity

In a fifth aspect, the invention relates to a pharmaceutical composition, hereinafter pharmaceutical composition of the invention, comprising fingolimod, an analogue, metabolite or derivative thereof or a pharmaceutically acceptable salt, and one or more drugs selected from the group consisting of an antioxidant, an antioxidant targeted to mitochondria, a histone deacetylase inhibitor, an inhibitor of mitochondria transition pore opening, an anti-inflammatory drug, a PPAR agonist, a RXR agonist, asirtuin1 agonist, an hypolipidemic drug and an autophagy activator

2.13.1.5 V717I (London mutation) Position 717 in the amyloid precursor protein (APP) is a well-established hotspot for mutations linked to autosomal dominant Alzheimers disease (ADAD)

M., Karpenko, O., Lindgren, V., Gaitonde, S., Gashkoff, P