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Thus, dietary fiber can break the inflammation-depression vicious cycle by reducing systemic inflammatory levels, thereby improving depressive symptoms (Figure 2)

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Over the past decades, a variety of downstream effector pathways and their connectivity have been elucidated [8], and it has been suggested that the conformational plasticity of GPCRs [9] and GPCR-transducer complexes also contribute to biased signaling and complexities of GPCR signaling [10, 11]