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Proceedings of the National Academy of Sciences of the United States of America, 107 (36), 1568115686

This is consistent with the fact that examination of the fatty-acid oxidation pathway in fibroblast culture did not reveal any abnormalities to explain the elevations in acyl-carnitines

CR impacts mitochondrial function and energy metabolism by upregulating superoxide dismutase 2 and activating the AMPK/silent information regulator sirtuin 1/Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha signaling pathway (Vo et al