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Research is ongoing, and the clinical significance of many MTHFR variants is still debated

Hesperidin has also shown efficacy in the case of acute neurological pathologies such as experimental hepatic encephalopathy caused by thioacetamide [241], restoring the redox balance, as demonstrated by the decrease in MDA in both the liver tissue and the brain by increasing sirtuin-1 expression and decreasing NLPR3 and IL-1beta

Furthermore, research has linked NLRP3 inflammasome activation with HIV-associated neuropathological changes, suggesting that HIV infection can induce harmful neuroinflammatory responses in the CNS (57)

Biochemistry 49:81348142