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Human clinical validation remains limited, which restricts confirmed medical use and standardized dosing protocols

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Parallel preclinical and clinical efforts targeting malaria, influenza, SARS-CoV-2, and human immunodeficiency virus (HIV) continue to refine VLP architectures for broader antigenic coverage, improved manufacturability, and enhanced stability under real-world deployment conditions (Collins et al., 2017

As research into combination therapies progresses, determining the optimal dosing regimens, identifying potential drug interactions, and ensuring long-term safety will be crucial to unlocking the full potential of this approach and maximizing its impact on obesity treatment