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Gene ontology and pathway analyses were performed using EnrichR ( Table S1 , and processed and filtered RNA-seq data is provided in Table S2

Adenovirus, adeno-associated virus, and plasmids Adenovirus type 5 overexpressing human CPT1A (AdCPT1A) was purchased from SignaGen Laboratories (Rockville, MD)

Glutathione Stransferase theta 1 protects against colitis through goblet cell differentiation via interleukin22

108,109 Members of the subfamily II of the SLC30 proteins (ZnT2, ZnT3, ZnT4, and ZnT8) play a major role in secretory tissues, with ZnT3 involved in neurotransmission, ZnT8 in insulin storage, ZnT4 in prostate secretion, and ZnT2 in lactation