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A separate study showed that TSA reduced Propionibacterium acnes-induced expression of pro-inflammatory factors (IL-1, IL-8, and TNF-) and activation of key proteins [TLR2, NF-B and intercellular adhesion molecule 1 (ICAM-1)] in the TLR2/NF-B signaling pathway in THP-1 cells, suggesting that TSA alleviates inflammation by blocking this pathway (41)

Therefore, mitochondrial dysfunction prevents cells from meeting their energy requirements and involves impairment of neuronal communication, cellular resilience, and hippocampal neurogenesis, which leads to mood and psychiatric disorders (Perkins et al., 1997

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