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Conversely, at a lower pH of approximately 6, aligning with the pI of sericin and gluten, the transformation of surface charge to positive for these nanocarriers enhances its affinity for cell membranes, thereby facilitating the facile internalization of MSN-PTA-SER and MSN-PTA-GLU by MCF-7 and ZR-751 cells (charge reversal effect)

Pulling the threads together, the experimental literature does suggest a real functional distinction provided one keeps the honesty caveats in view

The applicant clarified that not one of those claims have been for the use of the SCOUT MD TM Delivery System, because the device is not yet commercially available