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doi: 10.1002/hep.26237

Frequency is graded as 0 = Never, 1 = Rarely, 2 = Occasionally, 3 = Frequently, 4 = Almost constantly

JHU083 JHU083 is a prodrug form of L-DON designed to be cleaved by tissue proteases and other enzymes in the cancer, thereby limiting its effects on other organs [87, 102] (Fig