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The activation of microglia is regulated by pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs), which can recognize pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) (Li and Wu, 2021)

The third gap is that the antioxidant potential of bacteria-derived metabolites has been tested primarily in in vitro assays, and there are limited studies on in vivo models

Notably, the ratio of apoptotic cells in the TLR2 pep-orid-liposome group was significantly and positively associated with the expression level of TLR2 according to statistical results