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RMD Open 8 , e002255 (2022)

The elasticity and thickness of these disks effectively absorb daily impacts, safeguard the spine, uphold its natural curvature and flexibility, while also creating space for nerve roots to prevent compression and ensure normal transmission of nerve signals

Secondary injury refers to further molecular and chemical inflammatory reactions such as blood hemoglobin and iron release, dysfunction of brain metabolism and cerebral blood flow, further triggering neuroinflammatory processes, oxidative stress, glutamatergic excitotoxicity and mitochondrial dysfunction, etc., which cause further brain damage (Stocchetti et al., 2017)