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pylori ) is a gram-negative pathogen that colonizes gastric epithelial cells, and its chronic infection is the primary risk factor for the development of gastric cancer (GC)

2015 Nov;35(11):1052-62

Science 301, 13741377.10.1126/science.1086907 131 WedemayerG

This activation triggers the NF-B signaling cascade, leading to a transcriptional upregulation of pro-inflammatory cytokines (e.g., TNF-, IL-1, IL-6), chemokines, and adhesion molecules, which in turn recruit more immune cells to the injury site, and driving chronic inflammation and tissue damage (85)