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10.1016/j.brainres.2010.10.016 166 ReinerA.LevitzJ

IGF-1 LR3, DES(1-3) IGF-1, and PEG-MGF: IGF-1 Analogue Cluster IGF-1 LR3, DES(1-3) IGF-1, and PEG-MGF are three synthetic analogues of insulin-like growth factor 1 engineered for distinct half-life, IGFBP binding, and receptor-activation profiles

PKC, in turn, promotes an increase in cytosolic calcium concentration ([Ca 2+ ] (c) ), either directly by activating voltage-dependent calcium channels (Ca V ) or indirectly by inhibiting potassium (K + ) channels on the plasma membrane (Fukata et al., 2001)

High amounts of insulin and sugar in the blood lead to brain tissue damage and the brain is unable to carry out the functions needed for brain health