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Similarly, the leucine sensor SESTRIN was shown to be necessary for the dietary-restriction-induced lifespan extension in Drosophila , while a constitutively active SESTRIN mutant, that cannot bind leucine, downregulates TORC1 activity and is sufficient to promote longevity even in fed flies (Lu J

Among select SERPINA1 variants (protease inhibitor [Pi]*MS, Pi*MZ, Pi*SS, Pi*SZ, Pi*ZZ), the Pi*ZZ genotype carries the highest overall risk of AATD-LD