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VPA is extensively metabolized by the liver via glucuronic acid conjugation, mitochondrial and cytosolic (endoplasmic reticulum) -oxidation to produce multiple metabolites, some of which may be biologically active (Fig

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Methods Search Strategy This systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement ( Table S1 )

( D ) Viable cell counts of LNCaP-EV and LNCaP-MYC cell lines treated with VEH or SPA for 7 days ( n = 3 independent experiments)