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This poses a dual risk: while ENMs are often employed for their antimicrobial properties, their indiscriminate or chronic use could inadvertently select for resistant strains, complicating both clinical and ecological health management ( Given the breadth of these interactions, the current review aims to provide a comprehensive overview of the current understanding of ENMmicrobiome dynamics, the effects of various NMs on the human gut microbiota, aquatic and soil microbial ecosystems, and the potential for ENMs to influence microbial resistance development