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GC35139 4-Methylesculetin 4-Methylesculetin is an orally active natural coumarin derivative, with potent anti-oxidant and anti-inflammatory activities

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GSH is the bodys first line of defense against oxidative stress imposed from the outside world including but not limited to pollution, cigarette smoke, bacteria and viruses, amongst many other invaders

63,65 NF-B, as a key transcription factor, can lead to the overexpression of various pro-inflammatory genes with sustained activation, further enhancing local inflammation, creating a vicious cycle, and ultimately leading to abnormal follicular development and oocyte dysfunction