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Furthermore, excessive accumulation of NADH in conjunction with reduced NAD + availability can inhibit glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity in the glycolytic pathway, leading to glucose shunting to the glycolytic branch pathway (Yan et al., 2016

Antioxidants: Vitamin C and E and the Mediterranean Diet Since there is evidence relating oxidative damage of nerve cells to PD, some researchers are studying antioxidants substances often found in plants we eat that have cell-protection capability for their potential to slow Parkinson's progression

This approach helps to smooth out the concentration curve, minimizing the dramatic peak after dosing and the deep trough before the next dose