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(3) Targeting Vasocclusion Increased expression and activation of normally inactive erythroid adhesion molecules promote cytoadherence of sickle RBCs to the endothelium accompanied by platelets and leukocytes

Nucleic Acids Res 48:68556873

Disclosures: Teiji Kuzuya: Chugai Pharmaceutical Co: Speaking and Teaching, Eisai: Speaking and Teaching, Eli Lilly Japan: Speaking and Teaching, AstraZeneca: Speaking and Teaching, Naoto Kawabe: Nothing to Disclose, Yoshiki Hirooka: Nothing to Disclose 1822 A COMPARATIVE VALIDATION OF CLINICAL PREDICTION SCORES FOR HEPATOCELLULAR CARCINOMA IN STEATOTIC LIVER DISEASE WITHOUT CIRRHOSIS Catherine Mezzacappa 1 Janet Tate 1 Tamar Taddei 1 Amy Justice 1 , 1 Yale University Background: Many clinical risk scores to predict hepatocellular carcinoma (HCC) have been assessed in cohorts without known cirrhosis or viral hepatitis, whose HCC risk is driven by steatotic liver disease (SLD)

IGF-1 is one of the best-studied positive regulators of this cycle, promoting satellite-cell proliferation and differentiation and driving protein synthesis in mature fibers through the Akt/mTOR pathway