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Guinan J, Wang S, Hazbun TR et al (2019) Antibiotic-induced decreases in the levels of microbial-derived short-chain fatty acids correlate with increased gastrointestinal colonization of Candida albicans

Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J (2003) Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

Additionally, iontophoresis improved the penetration of 5-FU into viable epidermis compared to control liposomes, according to a depth permeation investigation which further lead to better in-vivo results in terms of tumor volume and area compared to conventional formulation

So and I can see a difference too