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These pseudotime-informed myogenic cell-state aggregates (summarized in Extended Data Fig

It typically presents as macrocytic megaloblastic anemia and neurological impairments, including sensory and motor disfunctions, predominantly in the lower extremities, ataxia, and in more advanced stages cognitive decline progressing to dementia, as well as psychiatric disturbances (Sanjay et al., 2022

Some clinical studies have reported noticeable improvements in hair density after six to twelve months

Mechanistically, the consistent threads are collagen up-regulation, angiogenesis support, and modulation of nitric-oxide pathways all of which are biologically plausible drivers of the observed soft-tissue effects