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APTES-COF-1@DOX and PEG-CCM were self-assembled as PEG-CCM@APTES-COF-1@DOX (c)

Hexahydroadiphenine) hydrochloride is an brain-penetrant antispasmodic agent

In parallel with cytokine delivery, being able to manage excessive or dysregulated cytokine activity is also important, particularly in conditions like COVID-19 and sepsis where cytokine storms can lead to severe immune imbalance (201, 202)