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Despite these improvements, ICD-10 remains the standard in most healthcare systems worldwide due to its long-standing integration in electronic health records, insurance, and billing processes

Pernicious anemia, one of the causes of vitamin B12 deficiency, is an autoimmune condition that prevents your body from absorbing vitamin B12

Keywords: vitamin B-12, cobalamin, proton-pump inhibitor, H 2 -receptor antagonist, metformin, holotranscobalamin, homocysteine, methylmalonic acid, multiple analyte testing Introduction There is general consensus that gastric acidlowering drugs, including proton pump inhibitors (PPIs) and H 2 -receptor antagonists (H2RAs), and the antidiabetes drug metformin can reduce circulating vitamin B-12 concentrations with prolonged use

Interestingly, TNF-alpha has been shown to interrupt tight junctions, thus worsening any underlying tight junction dysfunction