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Description

Failure to eliminate dysfunctional mitochondria leads to the accumulation of mitochondrial ROS and the release of immunogenic mtDNA, both of which act as DAMPs that activate innate immune pathways, including the NLRP3 inflammasome and type I interferon (IFN-I) signaling

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However, the main steps of fatty acids catabolism occur in the mitochondria

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Lesnikov VA, Pierpaoli W

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Its not a cure-all

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