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This transformation is readily taking place in pro-oxidative environments such as that created in hyperglycemic conditions (Luna et al

The diagrams in a - c , i , l and m were created using BioRender

Along with glutamine and glycine, it helps make and replenish glutathione

While the molecular pathogenesis of AxD remains incompletely understood, massive reactive astrogliosis with Rosenthal fibers composed of aggregated GFAP, vimentin, nestin, B-crystallin and small heatshock proteins together with prominent leukodystrophy are the pathological hallmarks, with the pathophysiological picture including mitochondrial malfunction, redox imbalance and susceptibility to oxidative stress 331,332,333