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67 Rapamycin was initially approved by the FDA in 1999 as an immunosuppressant for treating posttransplantation autoimmunity, which specifically suppresses the activity of mTORC1 in mTOR signaling and eventually disrupts cell proliferation and cell cycle progression of T cells while promoting immunosuppressive Treg development from nave T cells

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Superoxide radical scavenging by ascorbate is approximately 100 times more effective than that by glutathione (rate constants 3 10 5 M 1 s 1 vs 1 10 3 M 1 s 1 ) (Zhitkovich 2020)

The discovery of these markers is conducive to making early judgments about endocrine therapy efficacy and predictions of recurrence, which is helpful for doctors when making appropriate changes to the treatment strategy