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Inhibition of the PGE2 (prostaglandin E2) and cycloxigenase-2 (COX2) pathways, with consequent reduction in the expression of pro-inflammatory cytokines (IL-6, IL-8) and an increase in anti-inflammatory factors (cAMP, IL-10), was also observed in synovial fibroblasts from bovine and osteoarthritis patients ( Evidence from the literature thus shows that both ELF-MFs and PEMFs can affect signals associated with damage generally resulting in anti-inflammatory effects

However, under certain circumstances, pathobionts can translocate from the gut mucosa to the systemic circulation, leading to systemic inflammation and deleterious effects in CVDs progression [289]

Epithelial cells dynamically regulate the immune microenvironment by releasing mediators such as TSLP (149)