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Phase I: The Transformation In the first phase, the liver uses specialized enzymes to break down toxins

As a central transcription factor, NRF2 influences this cell death mode by inducing a variety of genes including SLC7A11, GPX4, FSP1, NQO1, HMOX1, ferritin heavy chain 1 (FTH1), HECT and RLD domain-containing E3 ubiquitin protein ligase 2, and vesicle-associated membrane protein 8 in hepatocellular carcinoma and ovarian cancer cells [85, 86]

In addition to the CHOP signaling pathway, eIF2, a direct substrate of the PERK pathway, has also been implicated in immune responses in IBD (93)