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Diabetes 2016;65:4452

Acting as signaling molecules, ROS are essential for the efficient and proper execution of a large number of cellular processes, such as regulation of intracellular signal transduction and gene expression patterns 1,2,3

Subsequent high-resolution confocal microscopy confirmed that vincristine induced cell cytoskeleton disorganization in which the DRG cell bodies became more porous, and microtubules were loosely packed after vincristine treatment