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The exact underlying mechanism that causes this disrupted iron homeostasis in the injured CNS is not known

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Piglets, dogs: 1-2 mL per head

Depending on the oxygen consumption rate, cells constitutively express different levels of antioxidant enzymes, including mitochondrial antioxidant manganese superoxide dismutase (Mn-SOD, SOD2), cytosolic copper-zinc superoxide dismutase (Cu, Zn-SOD, SOD1), glutathione peroxidase (GPX) and catalase (CAT), and the nonenzymatic antioxidant glutathione (GSH) [55] (Figure 1)