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And so, uh, cold-cold its kind of nice to know that, you know, cold does a lot of things that-that-that heat also does and vice versa

Ross et al., 2021)

The Trojan Horse hypothesis posits that the nanoparticle form facilitates uptake, subsequently dissolving within the acidic confines of organelles like lysosomes to deliver a highly concentrated dose of toxic ions.136,151 The pH-dependent dissolution of ZnO is a classic example:ZnO(s) + 2H+(aq) Zn2+(aq) + H2O(l)While this mechanism is compelling and supported by significant evidence,152 a critical perspective acknowledges the immense difficulty in experimentally deconvoluting these two toxicity vectors

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