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doi: 10.1097/CM9.0000000000001214 59 TersigniCVatishMD'IppolitoSScambiaGDi SimoneN

It refers to the wear and tear of spinal discs , which act as cushions between vertebrae

Front Neurol 12:609236 Petrillo S, Pietrafusa N, Trivisano M et al (2021) Imbalance of systemic redox biomarkers in children with epilepsy: role of ferroptosis [J]

In addition, in a rat renal ischemiareperfusion injury model, bardoxolone methyl decreased urea, creatinine, NGAL, total oxidant status, nitric oxide, and ADMA levels, increased SOD and GSH-Px activities, and upregulated renal Nrf2 and PPAR expression, suggesting that its anti-oxidative, anti-inflammatory, and anti-apoptotic effects collectively mitigate AKI severity (258)