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Drug synergism was measured using the Loewe model with Combenefit software (Cancer Research UK Cambridge Institute), and the combination index was calculated using CompuSyn software (ComboSyn) ( 3 Results 3.1 CB-839 treatment inhibits glutathione synthesis and the conversion of glutamine to glutamate in CLL cell lines Initially, we investigated CB-839s functional inhibition of GLS-1 ( Figures 1A, B )

This dual approach, direct tumor cell inhibition alongside immune modulation, positions AZD5153 as a potential enhancer for checkpoint inhibitor therapies, offering a promising combinatorial strategy to improve HGSOC patient outcomes (181)