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In a rat fracture model, IGF-1 combined with TGF- could stimulate chondrocyte proliferation and cartilage formation at the early stage of day 5 [8]

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Nuclear receptor coactivator 4 (NCOA4) can recognize ferritin and promote its autophagic degradation, leading to the release of free iron (22)

Finally, we discuss future research orientations that will lead to the clinical implementation of these novel ferroptosis modulators for treating a diverse range of diseases