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The interplay of local (within the diseased liver) and systemic inflammation, stemming from portal hypertension and alterations in the gut microbiome, alongside heightened levels of circulating cytokines, disrupts hepatic vagal neurogenic responses and impacts cerebral endothelial cells, giving rise to neuroinflammation

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In this metabolic process, curcumin is gradually reduced to a series of derivatives, including dihydrocurcumin, tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin

Packer L, Rimbach G, Virgili F