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Phase I studies from the late 1980s using IGF-1 to treat Larons Syndrome (GH insensitivity) revealed effective increase in linear growth reaching adult heights using doses ranging from 80 to 240 g/kg/day [264268]

There were no cases of glucose intolerance, insulin resistance, edema (fluid retention), joint pain, carpal tunnel syndrome, or other manifestations of excess growth hormone activity

Serenoa Serrulata Fruit Extract (Saw Palmetto): A powerful botanical often used as a natural alternative to pharmaceutical DHT blockers

The reference point is Lipinskis Rule of 5, an empirical framework from 1997 thats become one of the most cited ideas in drug research