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(2) ROS activates NF-B and MAPK signaling pathways, upregulating the expression of MMPs (MMP-13, MMP-3) and inflammatory factors (IL-1, TNF- ), thereby accelerating the degradation of type II collagen (Col-II) and proteoglycans

But given that two of three Americans will struggle with cognitive decline by age 70 and Alzheimers [disease] is now the sixth leading cause of death, I want to mention that curcumin has shown great promise in reducing cognitive decline and improving memory and focus

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The methionine salvage pathway is another crucial pathway for SAM production [151,152]