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Cyclooxygenase-2 is a crucial enzyme in the synthesis of eicosanoids

Lancet Digital Health 2, e286e287

Cuproptosis increases the stability of NFE2L2 by suppressing its proteasomal degradation, leading to transcriptional upregulation of GCLC and GCLM and enhanced GSH synthesis, thereby suppressing cuproptosis in pancreatic cancer cells 169