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Neurobiol Aging 28(9):14361445

Additionally, targeting is a critical factor in evaluating the performance of drug carrier systems

Mechanistically, OA suppresses pro-inflammatory cytokines (e.g., IL-17A, TNF-) by inhibiting nuclear factor kappa-B (NF-B) and signal transducer and activator of transcription 3 (STAT3) signaling pathways [8,9,10], attenuates oxidative stress via nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) axis activation [11, 12], and restores immune homeostasis by modulating Th17/Treg balance [9, 13]

Thus, the key to the upregulation of antioxidant enzyme activity by dietary polyphenols lies in the upregulation of transcription factor activity