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Abstract Glutathione peroxidase (GPx) is a selenocysteine-containing peroxidase enzyme that defends mammalian cells against oxidative stress, but the role of GPx signaling is poorly characterized

ATMs have two main phenotypes: M1 macrophages (M1) is considered the culprit of AT inflammation, can participate in glycolysis to rapidly produce ATP, and plays a key role in the initiation and maintenance of systemic inflammation and insulin resistance

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Cell culture and assays Total B cells and FoB/MZB were magnetically enriched from mouse spleen using a B cell or MZ and FO B Cell Isolation Kit, respectively (Miltenyi Biotec 130-090-862 and 130-100-366) as per manufacturers protocol