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Monitoring Progress and Adjusting Protocols Objective assessment of AOD-9604s effects requires proper measurement tools and regular evaluation

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ATF6, a key regulatory factor in ER stress (155), is essential for initiating the UPR triggered by pattern recognition receptors such as nucleotide-binding oligomerization domain-containing protein 2 (NOD2) (106)

Notably, comparisons of these analogs are limited because efruxifermin and pegbelfermin have been evaluated in patients with confirmed NASH, while BIO89-100 has been studied in patients with less severe NAFLD