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Study Design There were three experimental groups for this study (Figure 1): High intensity stimulus (HI, n=5), low intensity stimulus (LI, n=5), and nave unstimulated control (NC, n=5)

Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4

Kinetic analysis of drug release The rate at which the drugs were released from the tested mixtures was studied using the linear regression analysis method (R 2 )