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These iodine deficiency diets are usually applied in rodent models in an attempt to model human conditions of impaired production of thyroid hormones with subsequent enlargement of the thyroid gland

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ATF4-C/EBP homologous protein (CHOP) is an important pathway to regulate pathological phenomena such as ER stress, ROS production, lipid peroxidation, and iron metabolism, and inhibition of this pathway prevents the progression of ferroptosis-related diseases such as acute lung injury (45)