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The dose is gradually increased based on tolerance and effectiveness

Characteristics of biocommunity distribution For down-flow BAC bed, though there was a decreasing tendency of bacteria adsorbed on activated carbon from top of the carbon layer to the bottom, the variation tendencies of ammonifying bacteria, anti-vulcanization bacteria and denitrifying bacteria are not exactly the same, among which ammonifying bacteria showed a decreasing tendency from top of the carbon layer to the bottom

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[10] In clinical research settings and certain intensive protocols (such as addiction detoxification), much higher NAD+ dosages have been utilized