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Access this article Similar content being viewed by others Abbreviations PA : Perioperative anaphylaxis POH: Perioperative hypersensitivity US: United States of America ASA: American Society of Anesthesiologists ACE: Angiotensin converting enzyme IgE: Immunoglobulin E NAP6: National Audit Project 6 PAGS: Perioperative Anaphylaxis Grading System ISPAR: International Suspected Perioperative Allergy Group IV: Intravenous SC: Subcutaneous NMBA: Neuromuscular blocking agents UK: United Kingdom MRGPRX2: MAS Related GPR Family Member X2 HIV: Human immunodeficiency virus Hev b: Hevea brasiliensis FDA: Food and Drug Administration SPT: Skin prick test IDT: Intradermal testing IDHR: Immune-mediated drug hypersensitivity reaction DPT : Drug provocation test NSAID: Non-steroidal anti-inflammatory drugs References Cook TM, Harper NJN, Farmer L, Garcez T, Floss K, Marinho S, Torevell H, Warner A, McGuire N, Ferguson K, Hitchman J, Egner W, Kemp H, Thomas M, Lucas DN, Nasser S, Karanam S, Kong KL, Farooque S, Bellamy M, McGlennan A, Moonesinghe SR (2018) Anaesthesia, surgery, and life-threatening allergic reactions: protocol and methods of the 6th National Audit Project (NAP6) of the Royal College of Anaesthetists