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The continuous expression and function of GPX4 depend on the stable production of intracellular glutathione (GSH) (Ursini and Maiorino, 2020)

Therapeutic Use of Beta-Blockers Hypertension Angina Myocardial infarction Arrhythmias Heart failure Beta-blockers are used in the preoperative management of hypertension caused by a pheochromocytoma, which results in elevated circulating catecholamines

Extensive redundancy and compensatory flux within metabolic networks may compromise undermine the durability of single-pathway inhibition [89]

Window 6 weeks What Was Measured Improved ejection fraction, reduced fibrosis, and increased survival in pressure-overload heart failure